M. Chikviladze1, N. Mamulashvili1, L. Shanshiashvili1,2,, D. Mikeladze1,2.
1 Institute of Chemical Biology, Ilia State University, Tbilisi, Georgia
2 Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
Abstract
During demyelinating diseases, many peptide fragments and isomers of myelin basic protein are formed in the brain. They, together with pro-inflammatory agents, can strengthen the glial cell proliferation and neuron damage. Astrocytes are increasingly a source of cytotoxic mediators, rather than their targets. Among CNS alarmins, most impressive is IL-33 and galectin-3, which released from astrocytes and oligodendrocytes immediately after CNS injury and promoted inflammation or recovery following CNS Injury. We have studied whether myelin isomers have an effect on the release of IL-33 and Gal-3 in astrocytes. Our results have shown that the changes in the ratio of the C8 / C1 isomers can regulate the expression and production of these two cytokines – IL-33 and Gal-3 – and consequently, may influence the processes of myelination/demyelination/remyelination.